1 Cardiovascular Materials

In addition to PLA, there are also poly-L-lactic acid (PLLA) and poly-co-glycolic acid (PLGA), which are widely used in basic experiments and clinical applications.

Conventional atrial septal defect occluders were made of Nitinol, but they could not degrade in vivo. Some studies conducted in vitro tests of materials and related properties of the self-designed PLLA atrial septal defect occluding device, which showed that the performance of the PLLA atrial septal defect occluding device met the requirements of the occluding device in vitro tests, and had the characteristics of safety and degradation.

In other studies, amorphous calcium phosphate nanoparticles were incorporated on the basis of PLLA scaffold to prepare a new type of small blood vessel scaffold, which was placed into the coronary artery of miniature pigs. It was found that there were no significant changes in blood routine and biochemical indexes before and after stent implantation, and no myocardial infarction and inflammatory cell infiltration were observed around the scaffold, indicating that this new PLLA polymer could degrade the scaffold. It also has good safety, patency and biocompatibility.

2 Oral Materials

In the application of oral materials, hydroxyapatite and PLLA polymerization can improve the brittleness and poor mechanical properties of hydroxyapatite. In vitro experiments also showed that PLLA hydroxyapatite biomaterials had good cytocompatibility with periodontal cells.

3 Orthopedic stent

Bone morphogenetic protein Ⅱ (BMP-2) plays an important role in bone development and reconstruction. Some studies synthesized a new BMP-2 (specifically P24), added PLGA to construct a bionic composite scaffold material, and implanted in experimental mice. The results showed that P24/PLGA scaffold can induce more effective ectopic bone formation in vivo, and has good compatibility in vivo.

On the other hand, by preparing PLLA-silicate active fiber web scaffold, the results of in vitro studies with human osteosarcoma cells and human fat stem cells confirmed that this PLLA polymer scaffold is not cytotoxic to cells, and has the ability to promote cell adhesion and proliferation.